Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Determination of Isoprenyl and Lavandulyl Positions of Flavonoids from Sophora flavescens by NMR Experiment

  • Published : 1997.10.01
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Abstract

All fifteen flavonoids (1-15) have been isolated from the roots of Sophora flavescens (Leguminosae) as active principles of the cytotoxic property toward human tumor cell lines such as A549, SK-OV-3, SK-Mel-2, XF498 and HCT15, in vitro. By means of spectral analyses, particularlyby the aid of various two dimensional NMR experiments, all $^1H-NMR$ ad $^{13}C$ -NMR signals of 1-15 were completely assigned, and thus the structures of 1-15 were established unambiguously.

Keywords

References

  1. Phytochemistry v.29 Two flavonones in Sophora Ieachiano and some related structures Iinuma,M.;Tanaka,T.;Mizuno,M.;Shirataki,Y.;Yokoe,I.;Komatsu,M.;Lang,F.
  2. Arch. Pharm. Res. v.18 The structure of Kushenol M from Sophora flavescens Ryu,S.Y.;Lee,S.;No,Z.;Kim,K.;Lee,S.;Ahn,J.
  3. Planta Medica v.62 no.4 A novel flavonoid from Sophora flavescens Ryu,S.Y.;Kim,S.K.;No,Z.;Ahn,J.W.
  4. Phytotherapy Res. v.11 no.1 In vitro antitumor activity of flavonoids from Sophora flavescens Ryu,S.Y.;Choi,S.U.;Kim S.K.;No,Z.;Lee,C.O.;Ahn,J.W.;Kim,S.H.
  5. Chem. Pharm. Bull. v.11 Studies on the constituents of Japanese and Chinese Crude Drugs. Ⅶ. Shibata,S.;Nishikawa,Y.
  6. Chem. Pharm. Bull. v.33 no.8 Studies on the constituents of Sophora flavescens Ait. Ⅱ. Wu,L.;Miyase,T.;Ueno,A.;Kuroyanagi,M.;Noro,T.;Fukushima,S.
  7. Yakugaku Zasshi v.105 no.8 Studies on the constituents of Sophora flavescens Ait. Ⅲ. Wu,L.;Miyase,T.;Ueno,A.;Kuroyanagi,M.;Noro,T.;Fukushima,S.
  8. Yakugaku Zasshi v.105 no.11 Studies on the constituents of Sophora flavescens Ait. Ⅳ. Wu,L.;Miyase,T.;Ueno,A.;Kuroyanagi,M.;Noro,T.;Fukushima,S.;Sasaki,S.