Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Protective Effect of DA-9601, an Extract of Artemisiae Herba, against Naproxen-induced Gastric Damage in Arthritic Rats

  • Oh, Tae-Young (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Ryu, Byong-Kweon (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Ko, Jun-Il (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Ahn, Byoung-Ok (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Kim, Soon-Hoe (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co. Ltd) ;
  • Lee, Eun-Bang (Natural Products Institute, Seoul National University) ;
  • Jin, Joo-Hyun (Department of Gastroenterology, College of Medicine, Ajou University) ;
  • Hahm, Ki-Baik (Department of Gastroenterology, College of Medicine, Ajou University)
  • Published : 1997.10.01
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Abstract

Gastrointestinal irritation is the most frequent adverse effect in patients chronically taking nonsteroidal antiinflammatory drugs (NSAIDs) for the treatment of arthritic conditions. Gastroprotective effect of DA-9601, a new antiulcer agent from Artemisiae Herba extract, against NSAID was evaluated in a rat model of arthritis that is similar in many aspects to human rheumatoid arthritis. Daily oral dosing of naproxen (30 mg/kg), one of the most commonly used NSAID, induced apparent gastric lesions as well as a significant decrease in mucosal prostagiandin $E_2;(PGE_2)$ and prostagiandin F_${1{\alpha}}$$(PGF_{1{\alpha}})$ levels. Coadministration of DA-9601 prevents naproxen-induced mucosal injury and depletion of prostaglandins, in a dose-related manner. DA-9601 did not alter the antiinflammatory or analgesic effect of naproxen. The present results suggest that DA-9601 may be useful as a mucoprotectant against NSAIDs in clinical practice.

Keywords

References

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