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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of 4-Hydroxypiperidine Derivatives and Their Screening for Analgesic Activity

  • Saeed, M. (Department of Pharmacy, University of Peshawar) ;
  • Saify, Z.S. (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi) ;
  • Zafar Iqbal (Department of Pharmacy, University of Peshawar) ;
  • Nazar-ul-Islam (Department of Pharmacy, University of Peshawar)
  • Published : 1997.08.01
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Abstract

Six substituted phenacyl derivatives of 4-hydroxypiperidine were prepared and their structures were confirmed through spectroscopic techniques. These newly synthesized derivatives were also screened for analgesic activity by chemical and thermal methods. Only halogenated phenacyl derivatives demonstrated more or less protection against acetic acid induced writhing in mice where as rest of three derivatives were found inactive when screened by this chemical method. Similarly all the six derivatives were proved inactive by tail flick test.

Keywords

References

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