Archives of Pharmacal Research

  • 제20권4호
  • /
  • Pages.324-329
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  • 1997
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  • 0253-6269(pISSN)
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  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Clonazepam Release from Core-shell Type Nanoparticles In Vitro

  • Kim, Hyun-Jung (Department of Polymer Engineering, Chonnam National University) ;
  • Jeong, Young-Il (Department of Polymer Engineering, Chonnam National University) ;
  • Kim, Sung-Ho (College of Pharmacy, Chosun University) ;
  • Lee, Young-Moo (Department fo Industrial Chemistry, Hanyang University) ;
  • Cho, Chong-Su (Department fo Industrial Chemistry, Hanyang University)
  • 발행 : 1997.08.01
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초록

AB-type amphiphilic copolymers (abbreviated as LE) composed of poly (L-leucine) (PLL) as the A component and poly (ethylene oxide) (PEO) as the B component were synthesized by the ring-opening polymerization of L-leucine N-carboxy-anhydride initiated by methoxy polyoxyethylene amine $(Me-PEO-NH_2)$ and characterized. Core-shell type nanoparticles were prepared by the diafiltration method. Particle size distribution obtained by dynamic light scattering was dependent on PLL composition and the size for LE-1, LE-2 and LE-3 was $369.6{\pm}267$, $523.4{\pm}410$ and $561.2{\pm}364 nm$, respectively. Shapes of the nanoparticies observed by transmission electron microscope (TEM) were almostly spherical. The critical micelle concentration (CMC) of the nanoparticles determined by a fluorescence probe technique was dependent on the composition of hydrophobic PLL, and the CMC for LE-1, LE-2 and LE-3 was $2.0{\times}10^{-6},1.7{\times}10^{-6}$ and $1.5{\times}10^{-6}(mol/l) $, respectively. Clonazepam release from core-shell type nanoparticles in vitro was dependent on PLL composition and drug loading content.

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