Archives of Pharmacal Research
- 제20권3호
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- Pages.239-246
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Changes of Nitric Oxide Synthase Activity and Free Methylarginines Contents in Regenerating Rat Liver after Partial Hepatectomy
- Lee, Young-Jin (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
- Nam, Suk-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
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Seo, Dong-Wan
(Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
- Ahn, Seong-Hoon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
- Ko, Young-Kwon (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
- Sung, Dae-Suk (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
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Han, Jeung-Whan
(Department of Biochmistry, College of Pharmacy, Sungkyunkwan University) ;
- Hong, Sung-Youl (Department of Genetic Engineering, College of Life Science and Natural Resources, Sungkyunkwan University) ;
- Lee, Hyang-Woo (Department of Biochmistry, College of Pharmacy, Sungkyunkwan University)
- 발행 : 1997.06.01
초록
In the present study, liver regeneration rate (%) was increased up to 70% 3 days after partial hepatectomy (PH). Nitric oxide synthase (NOS) activity in liver tissue as well as serum nitrite/ nitrate content had no timed response, revealing no significant difference between shamoperated and partially hepatectomized rat liver. Contents of free methylarginines in liver tissue were increased biphasically in a time-dependent manner after PH. However, those in serum did not exhibit the same patterns as in liver. Taken together, the results suggest that