Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Anticomplementary Activity of Ergosterol Peroxide from Naematoloma fasciculare and Reassignment of NMR Data

  • Kim, Dong-Seon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Baek, Nam-In (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Oh, Sei-Ryang (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Jung, Keun-Young (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Lee, Im-Seon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Jung-Hee (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Lee, Hyeong-Kyu (Kyunghee University)
  • Published : 1997.06.01
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Abstract

A very high content (at least 0.23%) of ergosterol peroxide was isolated from Naematoloma fasciculare Karst. Not only ergosterol peroxide but also ergosterol showed very strong anticomplementary activity on the classical pathway, the $IC_{50}$ values being $5.0 {\mu}M$ and $1.0 {\mu}M$, respectively. The $ ^{1}H $and $^{13}C$ NMR data of ergosterol peroxide were revised and completely assigned by DEPT, $^{1}H-^{1}H$ COSY, HMQC and HMBC correlations.

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