Archives of Pharmacal Research
- Volume 20 Issue 2
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- Pages.122-127
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Suppression of Anaphylactic Reaction in Murine by Siegesbeckia pubescens
- Kim, Hyung-Min (College of Pharmacy, Wonkwang University) ;
- Kim, Chang-Young (College of Pharmacy, Wonkwang University) ;
- Kwon, Mun-Hyun (College of Oriental Medicine, Wonkwang, University) ;
- Shin, Tae-Yong (College of Pharmacy, Woosunk University) ;
- Lee, Eon-Jeong (College of Oriental Medicine, Wonkwang University)
- Published : 1997.04.01
Abstract
The aqueous extract of Siegesbeckia pubescens (SPAE) inhibited compound 48/80-induced systemic anaphylaxis 100% with the dose of 1.0, 0.5 mg/g body weight (BW) at 1 h before or 5 min, 10 min after intraperitoneal injection of compound 48/80. The passive cutaneous anaphylaxis (PCA) reaction also inhibited to 78.5% by oral administration of SPAE(1.0 mg/g BW). When SPAE pretreated on mice at concentrations ranging from 0.0001 to 1.0 mg/g BW, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SPAE (
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