Cytotoxic Constituents of Sorbaria sorbifolia var. stellipila

  • Kim, Dae-Keun (College of Pharmacy, Sung Kyun Kwan University) ;
  • Choi, Sang-Hoon (Korea Research Institute of Chemical Technology) ;
  • Lee, Jung-Ock (Korea Research Institute of Chemical Technology) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Park, Dae-Kyu (Chosun Pharm and Trading Co. Institute of Life Science Research) ;
  • Shin, Dae-Hee (Chosun Pharm and Trading Co. Institute of Life Science Research) ;
  • Jung, Jee-Hyung (College of Pharmacy, Pusan University) ;
  • Pyo, Suhk-Keung (College of Pharmacy, Sung Kyun Kwan University) ;
  • Lee, Kang-Ro (College of Pharmacy, Sung Kyun Kwan University) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sung Kyun Kwan University)
  • Published : 1997.02.01

Abstract

The activity-guided fractionation upon the MeOH extract of the aerial parts of Sorbaria sorbifolia var. stellipila led to the isolation of two cucurbitacin-compounds, cucurbitacin D and cucurbitacin F, as active principles. Two compounds were shown to exhibit significant cytotoxicity against cultured human tumor cell lines, A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT 15.

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