Archives of Pharmacal Research
- 제20권1호
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- Pages.53-57
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- 1997
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
The Effect of N-Substituted Alkyl Groups on the Anticonvulsant Activities of N-Cbz-${\alpha}$ -amino-N-alkylsuccinimides
- Lee, Jae-Won (Koshin Medical Center) ;
- Son, Ki-Chun (College of Pharmacy, Kyungsung University) ;
- Jung, Kyung-Im (College of Pharmacy, Kyungsung University) ;
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Choi, Jong-Won
(College of Pharmacy, Kyungsung University) ;
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Park, Min-Soo
(College of Pharmacy, Kyungsung University)
- 발행 : 1997.02.01
초록
For the purpose of defining the effects of the N-substituted alkyl groups on the anticonvulsant activities of N-Cbz-.alpha.-aminosuccinimides, various (R)- and (S)-N-alkyl substituted N-Cbz-.alpha.-aminosuccinimides (1 and 2) were prepared from the corresponding (R)- and (S)-N-Cbz-aspartic acid by using known reaction and were evaluated the anticonvulsant activies in the MES and PTZ tests, including their neurotoxicities. The most active compound in the MES test was (R)N-Cbz-.alpha.-amino-N-methylsuccinimide (1b)
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