Journal of Ginseng Research
- 제21권2호
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- Pages.132-140
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- 1997
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Ginsenoside $Rg_3$ 의 혈소판 응집 억제 효과 및 그 작용기전에 관한 연구
Inhibitory Effects of Ginsenoslde $Rg_3$ on Platelet Aggregation and its Mechanism of Action
초록
The effects of ginsenosides purified from red ginseng on platelet aggregation were investigated. Preincubation of washed platelets from rats with either ginsenoside Rg3, ginsenosides non-polar fraction (G-NPF), ginsenoside Rg1(Rg1) or ginsenosides polar fraction(G-PF) reduced the plytelet aggrelation induced by collagen in a dose-dependent manner, whereas ginsenoside Rg2 failed to inhibit the aggregation. Their IC50 values of Rg3, G-NPF, Rgl, and G-PF were 8.7