Journal of Ginseng Research
- Volume 21 Issue 2
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- Pages.132-140
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- 1997
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- 1226-8453(pISSN)
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- 2093-4947(eISSN)
Inhibitory Effects of Ginsenoslde $Rg_3$ on Platelet Aggregation and its Mechanism of Action
Ginsenoside $Rg_3$ 의 혈소판 응집 억제 효과 및 그 작용기전에 관한 연구
Abstract
The effects of ginsenosides purified from red ginseng on platelet aggregation were investigated. Preincubation of washed platelets from rats with either ginsenoside Rg3, ginsenosides non-polar fraction (G-NPF), ginsenoside Rg1(Rg1) or ginsenosides polar fraction(G-PF) reduced the plytelet aggrelation induced by collagen in a dose-dependent manner, whereas ginsenoside Rg2 failed to inhibit the aggregation. Their IC50 values of Rg3, G-NPF, Rgl, and G-PF were 8.7