Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Dosage Adjustment of Zinc

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  • Jung, So Young (College of Pharmacy, Seoul National University) ;
  • Shin, Wan Gyoon (College of Pharmacy, Seoul National University, Pharmacy Department, Seoul National University Hospital) ;
  • Kim, Ho Soon (Pharmacy Department, Seoul National University Hospital) ;
  • Cho, Nam Choon (Pharmacy Department, Seoul National University Hospital)
  • Published : 1997.12.01
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Abstract

Zinc is employed in body cell growth and immune function. Zinc deficiency causes growth retardation, night blindness, delay of wound healing, skin disorders, alopecia, et al. Pharmacokinetic study of zinc in Korean has not yet been proceeded to apply to patient. In this study, we investigated to adjust zinc dosage for maintaining constant zinc optimum serum level. Five NPO inpatients (3 males, 2 females) in Seoul National University of Hospital were evaluated, retrospectively. Zinc was mixed with parenteral nutrition solution and administrated intravenously in 24 hour-continuous infusion, and zinc dosage range was 0.17-0.45 mg/kg/day. AUC to zinc dose (AUC/Dose) was $2.421\pm1.007\;kg{\cdot}min/ml.$ 0.5 mg/kg/day zinc administration may achieve the plasma zinc concentration of $120\;{\mu}g/dl.$(Kor. J. Clin. Pharm. 1997; 7: 64-66)

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