Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Chilbokyeum(七福飮) on the Biochemical Changes in Brain Tissue of Senile Rats

칠복음(七福飮)이 노화(老化) 백서(白鼠) 뇌조직(腦組織)의 생화학적(生化學的) 변화(變化)에 미치는 영향(影響)

  • Son Jeong-Seok (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Won Kwang University) ;
  • Lyu Young-Su (Dept. of Oriental Neuropsychiatry College of Oriental Medicine, Won Kwang University)
  • 손정석 (원광대학교 한의과대학 신경정신과 교실) ;
  • 류영수 (원광대학교 한의과대학 신경정신과 교실)
  • Published : 1997.12.30
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Abstract

The present experiment was designed to examine catecholamines, 5-hydroxytryptamine, amino acids. malondialdehyde(MDA) and free radical scavenging activity, by administering Chilbokyeum extracts of a variety of concentration to senile brain rats. The results were summarized as followings ; 1. Chilbokyeum significantly increased noradrenalin in the hippocampus and hypothalamus of the brain tissue of senile rats, ad even though Chilbokyeum increased noradrenalin also in other brain tissue, there was no significance. 2. Chilbokyeum had no effects on dopamine changes in all brain tissue of senile rats.3. Chilbokyeum significantly increased 5-hydroxy-tryptamine in cerebellum, but decreased in other brain tissue.4. Chilbokyeum increased amino in the brain tissue of senile rats. 5. Chilbokyeum significantly decreased MDA and free radical in the brain tissue of senile rats. According to the above results, Chilbokyeum is assumed to improve brain function by reaction by reacting on biochemical of the senile brain, and that Chilbokyeum can be used to treat regressive brain disease carrying symptoms of psychoactive disorders.

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