대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

삼부탕(蔘附湯)이 실험동물(實驗動物)의 혈장지질함량(血漿脂質含量) 및 심혈관계(心血管系)에 미치는 영향(影響)

Effect of Sambutang on the Serum Cholesterol Levels and the Cardiovascular System in Experimental Animals

  • 최철원 (원광대학교 한의과대학 내과학교실) ;
  • 신선호 (원광대학교 한의과대학 내과학교실) ;
  • 문병순 (원광대학교 한의과대학 내과학교실)
  • Choi, Cheol-Won (Dept. of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Shin, Sun-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Byung-Soon (Dept. of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 발행 : 1997.06.30
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초록

The present experiment was designed to investigate the effects of Sambutang water extracts on the serum cholesterol levels and the cardiovascular system in the experimental animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurment of Mortality rate was observed for measuring the effect of Sambutang water extract. Sambutang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1 ml/10 g, 2 mg/kg) plus serotonin(5 mg/kg) in mouse. The effect of Sambutang water extract was examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as follows. 1. Sambutang decreased the serum cholesterol levels in rats. 2. Sambutang dropped the blood pressure in spontaneous hypertensive rat. 3. The drug increased the auricular blood flow in rabbit. 4. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 5. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen. 6. The drug inhibited the platelet aggregation in rat. 7. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 8. The drug increased the antithrombin activity in rat and the fibrinogen lysis time was reduced and lysis area was increased. 9. Sambutang reduced fibrinogen lysis time of rat in vitro assay. According to the above mentioned results. Sambutang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin activity, inhibited the platelet aggregation.

키워드

참고문헌

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