Journal of Pharmaceutical Investigation
- 제27권3호
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- Pages.233-239
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- 1997
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
글리벤클라미드 결정다형의 용출
Dissolution of Glibenclamide Polymorphs
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Sohn, Young-Taek
(College of Pharmacy, DukSung Women's University) ;
- Um, Bo-Young (College of Pharmacy, DukSung Women's University)
- 발행 : 1997.09.20
초록
Glibenclamide is a second generation sulfonylurea that is orally active as a hypoglycemic drug. It exists as a crystalline powder which is sparingly soluble in water. It was investigated that the potential of glibenclamide to exhibit polymorphism. Three polymorphic modifications (form 1, form 2 and form 3) and three pseudopolymorphic modifications (form 4, form 5 and form 6) were obtained by crystallization from different organic solvents. The isolated crystal forms were characterized by differential scanning calorimetry(DSC), thermogravimetric analysis(TGA) and X-ray crystallography powder diffraction studies. Form 1 was the most stable and melt at