Journal of Pharmaceutical Investigation
- Volume 27 Issue 3
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- Pages.165-171
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- 1997
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Inclusion Complex of Analgesic and antiinflammatory Agents with Cyclodextrins (II) : Effect of $2-Hydroxypropyl-{\beta}-cyclodextrin$ on the Release of Ibuprofen Suppository
시클로덱스트린과 소염진통제간의 포접복합체에 관한 연구 (II) : 2-히드록시프로필-${\beta}$ -시클로덱스트린이 이부프로펜 좌제의 방출에 미치는 영향
- Oh, In-Joon (College of Pharmacy, Chonnam National University) ;
- Lee, Mi-Young (College of Pharmacy, Chonnam National University) ;
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Lee, Yong-Bok
(College of Pharmacy, Chonnam National University) ;
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Shin, Sang-Chul
(College of Pharmacy, Chonnam National University)
- Published : 1997.09.20
Abstract
Ibuprofen, a nonsteroidal antiinflammatory, analgesic and antipyretic drug, has several limitations in clinical application because of low solubility in water and gastrointestinal irritation. Effect of ibuprofen/
Keywords
- Ibuprofen;
- $Hydroxypropyl-{\beta}-cyclodextrin$;
- Inclusion compound;
- Complexation;
- Suppository;
- Rectal absorption