Journal of Pharmaceutical Investigation
- 제27권2호
- /
- Pages.119-123
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- 1997
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- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
새로운 Capsaicin 유도체 DA-5018의 구조 및 물리화학적 성질 연구
Structural and Physicochemical Studies on DA-5018, a New Capsaicin Derivative
- 김흥재 (동아제약(주)연구소) ;
-
이종진
(동아제약(주)연구소)
;
- 이응두 (동아제약(주)연구소) ;
- 심현주 (동아제약(주)연구소) ;
- 이상득 (동아제약(주)연구소) ;
- 옥광대 (동아제약(주)연구소) ;
-
김원배
(동아제약(주)연구소)
;
- 박노상 (한국화학연구소)
- Kim, Heung-Jae (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
-
Lee, Jong-Jin
(Research Laboratories, Dong-A Pharm. Co., Ltd.)
;
- Lee, Eung-Doo (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Shim, Hyun-Joo (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Lee, Sang-Deuk (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
- Ok, Kwang-Dae (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
-
Kim, Won-Bae
(Research Laboratories, Dong-A Pharm. Co., Ltd.)
;
- Park, No-Sang (Korea Research Institute of Chemical Technology (KRICT) Division of Medicinal Chemistry)
- 발행 : 1997.06.20
초록
The physicochemical and structural properties of new capsaicin derivative, DA-5018, were examined. The reference standard of this compound was obtained by the recrystallization. A method for the determination of the dissociation constant of the compound is described. pH-solubility and distribution coefficient were determined by chromatographic method. Fundamental properties on thermal behaviors were investigated by TG, DTA and DSC. Structural analysis based on spectroscopic method coincided with the chemical structure of DA-5018. Approximate dissociation constant of the compound determined by UV spectral method was 9.35. Solubilities and partition coefficients in various pH buffer solution appeared pH-dependency. No crystal transition or further transition was found in the thermal analysis. This compound showed good stability, but pH 13 buffer and acetone made some degradative products.
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