Journal of Pharmaceutical Investigation
- 제27권1호
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- Pages.29-38
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- 1997
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
바이칼린 함유 생약의 제제화 및 생체이용률 (제3보) : 황금 및 황련 공침물의 포접화합물 제조 및 생체이용률에 관한 연구
Preparation and Bioavailability of Oriental Medicine Containing Baicalin (III) : Preparation of Inclusion Complex and Bioavailability of Coprecipitated Product of Scutellariae Radix and Coptidis Rhizoma
- Yang, Jae-Heon (College of Pharmacy, Woosuk University) ;
- Shin, Sang-Chul (College of Pharmacy, Chonnam National University) ;
- Yoo, Hee-Doo (College of Pharmacy, Woosuk University)
- 발행 : 1997.03.20
초록
Precipitation was formed during the preparation of decoction from a mixture of Scutellariae Radix and Coptidis Rhizoma. Baicalin and berberine were identified in this coprecipitated product (CPP) and these components were the active ingredients of two herbal medicine. We extracted respectively crude baicalin and berberine in Scutellariae Radix and Coptidis Rhizoma and prepared coprecipitate of crude baicalin-berberine. To increase the stability and bioavailability of coprecipitate of crude baicalin-berberine(CBB), which is slightly soluble drug, its inclusion complex was prepared and studied in this experiment. Inclusion complex of CBB with
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