Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidants in Leaves of Rosa rugosa

해당화(Rosa rugosa) 잎의 항산화물질

  • Choi, Yong-Hwa (Plant Biochemistry Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kim, Myong-Jo (Plant Biochemistry Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Heang-Soon (Plant Biochemistry Research Unit, Korea Research Institute of Bioscience and Biotechnology) ;
  • Hu, Chang-Xu (Phytopharmaceutical Laboratory, Institute of Botany) ;
  • Kwak, Sang-Soo (Plant Biochemistry Research Unit, Korea Research Institute of Bioscience and Biotechnology)
  • 최용화 (생명공학연구소 식물생화학 Research Unit) ;
  • 김명조 (생명공학연구소 식물생화학 Research Unit) ;
  • 이행순 (생명공학연구소 식물생화학 Research Unit) ;
  • 호창서 (중국과학원 식물연구소) ;
  • 곽상수 (생명공학연구소 식물생화학 Research Unit)
  • Published : 1997.12.30
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Abstract

To search for useful antioxidants from plant materials, we investigated the antioxidative activity in the methanol extracts of 30 Chinese medicinal plants using DPPH method. The highest activity $(RC_{50}:\;12\;{\mu}g)$ was showed in the methanol extract of Rosa rugosa, followed by Potentilla fruticosa $(14\;{\mu}g)$, P. fragarioides $(16\;{\mu}g)$. And Geum aleppicum $(18\;{\mu}g)$. From the leaves of R. rugosa, two antioxidative compounds were isolated by a bioassay guided purification and identified as isoquercitrin and ${\beta}-glucogallin$ on the basis of $^1H-,\;^{13}C-\;NMR$, and FAB-MS data. ${\beta}-Glucogallin$ is the first report in this plant. The DPPH radical scavenging activity of ${\beta}-glucogallin\;(RC_{50}:\;8.5\;{\mu}g)$ was more effective than those of ${\alpha}-tocopherol\;(12\;{\mu}g)$ and BHA $(14\;{\mu}g)$.

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