생약학회지 (Korean Journal of Pharmacognosy)
- 제28권3호
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- Pages.99-103
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- 1997
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
충치균, Streptococcus mutans OMZ176에 대한 황금의 항균활성성분
Antibacterial Constituents from Scutellariae Radix against Streptococcus mutans OMZ176
- Moon, Yong-Hyup (College of Pharmacy, Chungnam National University) ;
- Lee, You-Hui (Korea Ginseng & Tobacco Research Institute) ;
- Min, Byung-Sun (College of Pharmacy, Chungnam National University) ;
- Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
- 발행 : 1997.09.30
초록
To develop anticariogenic agents, Scutellariae Radix was tested for its antibacterial activity against Streptococcus mutans OMZ176 which is known as a strong cariogenic bacterium. The antibacterial activity was evaluated with disk plate method and minimal inhibitory concentration (MIC). The ethyl acetate fraction showed significant activity. By means of activity-guided fractionation, baicalein and ganhuangenin were isolated as the active principles. The MICs of these compounds were