생약학회지 (Korean Journal of Pharmacognosy)
- 제28권3호
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- Pages.149-155
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- 1997
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
안태음의 변이원성 및 간독성에 관한 연구
Studies on the Mutagenicity and Hepatotoxicity of Antaeum
- 이동녕 (동국대학교 한의과대학) ;
-
문진영
(동국대학교 한의과대학) ;
- 오규석 (동국대학교 한의과대학) ;
- 이태균 (동국대학교 한의과대학) ;
- 최미정 (동국대학교 의과대학) ;
- 이동목 (대구대학교 자연자원대학) ;
-
남경수
(동국대학교 의과대학)
- Lee, Dong-Nyung (College of Oriental Medicine, Dongguk University) ;
-
Moon, Jin-Young
(College of Oriental Medicine, Dongguk University) ;
- Oh, Gue-Suc (College of Oriental Medicine, Dongguk University) ;
- Lee, Tae-Kyun (College of Oriental Medicine, Dongguk University) ;
- Choi, Mi-Jung (College of Medicine, Dongguk University) ;
- Lee, Dong-Mok (College of Natural Resources, Daegu University) ;
-
Nam, Kyung-Soo
(College of Medicine, Dongguk University)
- 발행 : 1997.09.30
초록
Antaeum(ATE) has been used as a prescription for threatened abortion, associated with pregnancy in traditional medicine. Because gravida could be administered ATE for a long period, its administration might cause a harmful effect on fetus and gravida during the pregnancy. This study aimed to determine whether exposure to ATE caused mutagenicity or hepatotoxicity during the pregnant period. For mutagenicity test of ATE, Salmonella typhimurium and Bacillus subtilis were used as indications for DNA damage. In the Ames test, Samonella typhimurium TA98 and TA100 were used for mutagenicity testing, and the number of histidine revertants was measured. In Rec-assay, Bacillus subtilis H