Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Antimutagenic Activity of the Methanol Extract and Compounds of Angelica keiskei in the Salmonella Assay System

  • Park, Jong-Cheol (Department of Oriental Medicine Resources, Sunchon National University) ;
  • Park, Jeong-Ro (Department of Food and Nutrition, Sunchon National University) ;
  • Chung, Shin-Kyo (Department of Food Science ond Technology, Kyongpook National University) ;
  • Yu, Young-Beob (Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University) ;
  • Ha, Jung-Ok (Department of Food Science and Nutrition, Pusan National University) ;
  • Park, Kun-Young (Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University)
  • Published : 1997.06.30
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Abstract

The methanol extract of aerial part of Angelica keiskei Koidzumi exhibited a strong antimutagenic activity against aflatoxin $B_1\;(AFB_1)$. N-methyl-N'-nitro-N-nitrosoguanidine and 4-nitroquinoline-1-oxide in the Ames test with Salmonella typhimurium TA100. Cynaroside, isolated front ethylacetate fraction of the methanol extract Over silica gel, inhibited the mutagenicity of $AFB_1$ with an inhibition value of 96% at 1.0 mg/plate concentration and 87% at 0.5 mg/plate concentration. Other compounds, hyperoside, sucrose and luteolin-7-rutinoside, isolated from ethylactate or n-butanol fraction, also showed antimutagenic effect.

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