Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Modulation of Hepatic Lipid Peroxidation and Antioxidant Defenses by Wild Plants Extracts

야생초 추출물에 의한 간장내 활성산소 생성과 항산화 효소계 조절에 관한 연구

  • Lee, Sang-Young (Division of Food and Biotechnology, Kangwon National University) ;
  • Kim, Sung-Wan (Department of Biochemistry, Kangwon National University) ;
  • Kim, Jong-Dai (Division of Food and Biotechnology, Kangwon National University)
  • 이상영 (강원대학교 농업생명과학대학 식품,생명공학부) ;
  • 김성완 (강원대학교 자연과학대학 생화학과) ;
  • 김종대 (강원대학교 농업생명과학대학 식품,생명공학부)
  • Published : 1997.03.30
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Abstract

This study was performed to elucidate the possible antioxidative effects of several wild plant extracts. Wild plants were extracted with methanol or water using general method. In first experiments, antioxidative effects were measured by lipid peroxidation using rat brain homogenate. Coptis japonica extract showed the highest antioxidative activity among the 15 wild plant extracts. In second experiments, rats were fed on the semipurified diets with or without Coptis japonica extracts at the level of 0.5% for 4 weeks. MDA production of liver homogenate were significantly lower in the rats fed Coptis japonica extracts (P<0.05). Cytosolic catalase. GPX, and SOD activities were not changed, whereas the activities of GST and glutathione level were significantly higher in rats fed Coptis japonica extracts (P<0.05). These results suggest that Coptis japonica extract has an antioxidative effect through increasing GST activity and glutathione level and decreasing MDA production.

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