The Korean Journal of Physiology and Pharmacology
- Volume 1 Issue 5
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- Pages.597-602
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Cytochrome P450 2E1 Activity in a Korean Population
- Muhn, Dou-Hyun (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Chae, Ji-Min (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Bahn, Jae-Yong (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Song, Hae-Jung (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Kim, Hyung-Kee (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Kwon, Jun-Tack (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine) ;
- Sohn, Dong-Ryul (Department of Clinical Pharmacology, Soonchunhyang University College of Medicine)
- Published : 1997.10.21
Abstract
Cytochrome P450 2E1 (CYP2E1) is involved in the toxicity and carcinogenicity of a number of solvents and xenobiotics. Like the various types of oxidation pharmacogenetics, the activity of the enzyme shows a discernible interindividual and interethnic variation. However, no pharmacogenetic information on CYP2E1 polymorphism has been available from a Korean population. The aim of this study was to explore the pharmacogenetics of CYP2E1 polymorphism in a native Koreans after an oral 400 mg dose of chlorzoxazone administered to 128 subjects. Urine samples were collected during the subsequent 8-hour period and urinary concentrations of chlorzoxazone and 6-hydroxychlorzoxazone were determined by a high performance liquid chromatography with an ultraviolet detector. The limit of detection in the samples was found to be