The Korean Journal of Physiology and Pharmacology
- 제1권2호
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- Pages.221-224
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- 1997
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- 1226-4512(pISSN)
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- 2093-3827(eISSN)
Melatonin Enhances Hepatic Glutathione-peroxidase Activity in Sprague-Dawley Rats
- Kim, Choong-Yong (ARRC, Kon-Kuk University) ;
- Yun, Choong-Soon (Pharmacol. & Toxicol. Lab., Dept. of Vet. Medicine. Kon-Kuk University) ;
- Park, Dae-Hun (Pharmacol. & Toxicol. Lab., Dept. of Vet. Medicine. Kon-Kuk University) ;
- Choi, Woo-Sung (Pharmacol. & Toxicol. Lab., Dept. of Vet. Medicine. Kon-Kuk University) ;
- Kim, Jin-Suk (Pharmacol. & Toxicol. Lab., Dept. of Vet. Medicine. Kon-Kuk University)
- 발행 : 1997.04.21
초록
Effects of melatonin on hepatic glutathione-peroxidase (GSH-Px) and glutathione-reductase (GSH-reductase) activities were studied in Sprague-Dawley (SD) rats administered i.p. (10 mg/kg body weight) with melatonin during 15 days. The activity of cytosolic GSH-reductase in the liver was not changed by melatonin. However, melatonin injection increased significantly the activity of liver cytosolic GSH-Px activity compared with those in saline-treated rats. At the same time, plasma GSH-Px was also increased significantly in melatonin-treated rats. Since GSH-Px, a major antioxidative enzyme, removes