생물정신의학 (Korean Journal of Biological Psychiatry)
- 제3권2호
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- Pages.269-276
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- 1996
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
Fluoxetine 병용 투여 후 만성 정신분열증 환자에서 혈장 5-Hydroxyindoleacetic Acid 농도에 따른 Hamilton Rating Scale for Depression의 변화
Changes of Hamilton Rating Scale for Depression According to Plasma 5-Hydroxyindoleacetic Acid Level after Adjuntive Fluoxetine Trial in Schizophrenic Patients
- Shim, Se Hoon (Department of Neuropsychiatry, School of Medicine, Soonchunhyang University) ;
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Jung, Han Yong
(Department of Neuropsychiatry, School of Medicine, Soonchunhyang University) ;
- Han, Sun Ho (Department of Neuropsychiatry, School of Medicine, Soonchunhyang University)
- 발행 : 1996.12.25
초록
Object : The aim of this study was to examine an association between plasma 5-Hydroxyindoleacetic Acid(HIAA) level and the change of depressive symptom after fluoxetine trial in haloperidol-stabilized schizoprenic in-patients. Method : According to plasma 5-HIM level, 32 patients were classified to either group with high 5-HIAA level(N=11) or that with low 5-HIM(N=11). For each patient, fluoxetine(20mg/day) added to stable haloperidol dose for 6 weeks. The authors measured Hamilton Rating Scale for Depression (HRSD) at baseline, the 2nd week, the 4th week, the 6th week of treatment. Result : 1) Age, duration of illness, number of admission, duration of present admission, dosage of haloperidol between high 5-HIAA group and low 5-HIM group were significantly different. 2) As time went on, the association between the change of depressive symptom and plasma 5-HIAA concentration was not significant. 3) Of depressed group, as lime went an, depressive symptoms were improved significantly in high 5-HIAA group, but not in law 5-HIM group. Conclusion : We suggest that the association between plasma 5-HIAA level and the change of depressive symptoms after fluoxetine trial in haloperidol stabilized schizophrenic in-patients was not significant.