A Study on NADPH-Diaphorase and Neuropeptide Y-Positive Neurons in The Brain Stem of Aged Rats

노화된 흰쥐의 뇌줄기에 분포하는 NADPH-Diaphorase 및 Neuropeptide Y양성 신경세포에 관한 연구

  • Kim, Soon-Hee (Department of Neuropsychiatry, Chung Gu Sung Shim Hospital) ;
  • Chang, Hwan-Il (Department of Neuropsychiatry, Kyung Hee University College of Medicine) ;
  • Huh, Young-Buhm (Department of Anatomy, Kyung Hee University College of Medicine) ;
  • Ahn, Hee-Kyung (Department of Anatomy, Kyung Hee University College of Medicine)
  • 김순희 (청구성심병원 신경정신과) ;
  • 장환일 (경희대학교 의과대학 신경정신과학교실) ;
  • 허영범 (경희대학교 의과대학 해부학교실) ;
  • 안희경 (경희대학교 의과대학 해부학교실)
  • Published : 1996.12.25

Abstract

This study was aimed to charily the change of NADPH-diaphorase(NADPH-d) and neuropeptide Y(NPY) associated with aging of the rots. To verily the effect of aging of NPY and NADPH-d-positive neurons in the brain stem, the neurons were stained by the immunohistochemical and histochemical method. In the aged group, the number of NADPH-d-positive neurons was significantly decreased in substantia nigra lateralis, supragenual nucleus, raphe magnus nucleus and raphe obscurus nucleus as compared with control group. The number of NADPH-d-positive neurons was not significantly decreased in superior colliculus, interpeduncular nucleus, central gray. dorsal raphe nucleus, retrorubral nucleus, pedunculopontine tegmental nucleus, laterodorsal tegmental nucleus, pontine reticular nucleus, prepositus hypoglossal nucleus and nucleus solitarius of the aged rats. The NADPH-d and NPY-positive neurons were found in the interpeduncular nucleus, central gray, substantia nigra lateralis, laterodorsal tegmental nucleus, nucleus solitarius, raphe magnus nucleus, raphe obscurus nucleus of the control and aged groups. The coexistence of NADPH-d and NPY in the some cell was not found in the brain stem of both groups.

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