Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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Behavioral Response and Immune Alterations by Electric Footshock in Mice

생쥐에서 전기자극 스트레스에 의한 행동반응과 면역 기능 변화

  • Kim, Jung-Bum (Department of Psychiatry, Keimyung University, School of Medicine, Institute for Medical Science) ;
  • Park, Won-Kyun (Department of Physiology, Keimyung University, School of Medicine, Institute for Medical Science) ;
  • Song, Dae-Kyu (Department of Physiology, Keimyung University, School of Medicine, Institute for Medical Science)
  • 김정범 (계명대학교 의과대학 정신과학교실 및 의과학연구소) ;
  • 박원균 (계명대학교 의과대학 생리학교실 및 의과학연구소) ;
  • 송대규 (계명대학교 의과대학 생리학교실 및 의과학연구소)
  • Published : 1996.06.15
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Abstract

The present experiment was designed to investigate the effects of behavioral, response to immune function in response to electric footshock in mice. Mice were subjected to electric footshock for 3 days(two sessions a day, 11 times of shock for about 31 minutes a session). The humoral immune response was measured using mice immunized with rat RBC. The cell-mediated immune responses were evaluated by contact hypersensitivity to 2, 4-dinitrofluorobenzene(DNFB) and by phytohemagglutin(PHA)-stimulated splenocytes proliferation assay. In stressed group, electric footshock suppressed significantly anti-rat RBC antibody production(p<0.05), but enhanced significantly $T_{48}$ relative to $T_{24}$ in contact hypersenstivry (P<.01) and T-cell proliferation response(P<.05) by PHA stimulation elative to control group. T-cell proliferation response by PHA stimulation was significantly correlated to the movement than the sensitivity and coping behavior in the mouse, in response to the electric footshock. These data supper the importance of behavioral response in stress-induced changes of immune functions.

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