The Journal of the Korean bone and joint tumor society (대한골관절종양학회지)
- Volume 2 Issue 1
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- Pages.72-77
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- 1996
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- 1226-4962(pISSN)
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- 2233-9841(eISSN)
Effect and Tolerability of Nasal Spray of Salmon Calcitonin in the Relief of Pain due to Bone Metastasis
전이성골암에 의한 통증에 대한 Salmon Calcitonin($Miacalcic^{(R)}$ ) 비강분무의 효능 및 안정성
- Lee, Soo-Yong (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Jeon, Dae-Geun (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Lee, Jong-Seok (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Kim, Sug-Jun (Department of Orthopedic Surgery, Korea Cancer Center Hospital) ;
- Hong, Seok-Il (Department of Clinical Pathology, Korea Cancer Center Hospital) ;
- Choi, Soo-Yong (Laboratory of Clinical Research, Korea Cancer Center Hospital) ;
- Jang, Jin-Dae (Department of Orthopedic Surgery, Korea Cancer Center Hospital)
- 이수용 (원자력병원 정형외과) ;
- 전대근 (원자력병원 정형외과) ;
- 이종석 (원자력병원 정형외과) ;
- 김석준 (원자력병원 정형외과) ;
- 홍석일 (원자력병원 임상병리과) ;
- 최수용 (원자력병원 임상의학연구실) ;
- 장진대 (원자력병원 정형외과)
- Published : 1996.04.30
Abstract
Metastaic bone tumors are usually accompanied with severe pain. The treatment modalities for this pain are so variable that patients are sometimes afraid of using them. Salmon calcitonin has a function to increase beta-endorphines followed by increasing the blood level of prostaglandin and thromboxan A2, which results in analgesic effect. This drug also has been known to decrease bone resorption. There were a few reports that parenteral use of salmon calcitonin decrease the pain from metastatic bone tumor. We wanted to know the effectiveness and tolerability of nasal spray of salmon calcitonin in relieving bone pain with metastatic tumor. We analyzed the effectiveness in the aspects of pain, sleep, performance status, mobility, supplementary analgesic use. The biologic effect of salmon calcitonin was analysed with CBC, Ca/P, BUN/Cr, uric acid. Simple radiography, alkaline phosphatase, osteocalcin, pyrilink-K were used as parameters for bone change. Eighteen cases of metastatic bone tumors took nasal spray of salmon calcitonin(