Tuberculosis and Respiratory Diseases
- Volume 43 Issue 1
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- Pages.8-13
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- 1996
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
The Relationship between Isoniazid Resistance and 463 CodonMutation of katG Gne in Mycobacterium Tuberculosis
결핵균 katG 유전자내 463 Codon 돌연변이와 Isoniazid내성 관계
- Park, Young-Kil (Korean Institute of Tuberculosis, Korean National Tuberculosis Association) ;
- Shim, Myung-Sup (Korean Institute of Tuberculosis, Korean National Tuberculosis Association) ;
- Cho, Sang-Hyun (Korean Institute of Tuberculosis, Korean National Tuberculosis Association) ;
- Bai, Gill-Han (Korean Institute of Tuberculosis, Korean National Tuberculosis Association) ;
- Kim, Sang-Jae (Korean Institute of Tuberculosis, Korean National Tuberculosis Association)
- 박영길 (대한결핵협회 결핵연구원) ;
- 심명섭 (대한결핵협회 결핵연구원) ;
- 조상현 (대한결핵협회 결핵연구원) ;
- 배길한 (대한결핵협회 결핵연구원) ;
- 김상재 (대한결핵협회 결핵연구원)
- Published : 1996.02.29
Abstract
Background: The 463 codon mutation of katG gene has been reported as an useful marker for the detection of isoniazid(INH) resistant strains of M. tuberculosis. This study aimed to elucidate relationship between 463 mutation in katG gene and INH resistance in M. tuberculosis. Method: DNA was extracted from 28 INH susceptible strains(MIC
연구배경: 결핵균 katG유전자내 463 codon의 돌연변이는 INH 내성과 관련이 있을 것으로 보고되고 있어서 INH 감수성 균주를 대상으로 katG 유전자내 463 codon의 돌연변이 발생빈도를 관찰하여 INH 내성과의 관련성을 밝히고자 하였다. 방법: INH 감수성 균주(MIC