The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Prophylactic Effects of Transdermal Scopolamine Patches on Nausea in Postoperative Patients Receiving Epidural Morphine

술후 통증 치료를 위한 몰핀 경막외 주입시 경피적 Scopolamine에 의한 구역 예방 효과

  • Kim, Jae-Wan (Department of Anesthesiology, College of Medicine, University of Ulsan) ;
  • Lee, Cheong (Department of Anesthesiology, College of Medicine, University of Ulsan) ;
  • Suh, Byung-Tae (Department of Anesthesiology, College of Medicine, University of Ulsan)
  • 김재완 (울산대학교 의과대학 마취과학교실) ;
  • 이청 (울산대학교 의과대학 마취과학교실) ;
  • 서병태 (울산대학교 의과대학 마취과학교실)
  • Published : 1996.06.01
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Abstract

Background: To evaluate the effect of prophylactic transdermal scopolamine in reducing nausea associated with postoperative epidural morphine. Methods: 30 healthy patients scheduled for cesarean section were given local anesthetics epidurally for surgical anesthesia. After delivery of the baby, transdermal scopolamine patch($Kimite^{(R)}$ Myung Moon Pharm. Co., Seoul, Korea) was applied to the study group(n=15) and placebo patch to the control group(n=15). Postoperative analgesia was provided soley with epidural morphine. Nausea was treated with metoclopramide. Results: During 24 hours postoperatively, the mean nausea score was significantly lower in the study group than in the control group. But the nausea incidence was not significantly different between the two groups. The mean number of times antiemetic drugs which were administered to patients were lower in the study group than in the control group($1.5{\pm}0.5$ vs $3.3{\pm}1.3$, p<0.05). Conclusion: Transdermal scopolamine patch provides antiemetic effect simply, continuously and safely, preventing nausea which could occur during administration of epidural morphine after cesarean section.

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