Tuberculosis and Respiratory Diseases
- Volume 43 Issue 6
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- Pages.862-870
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- 1996
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
Treatment Results of Multidrug Resistant Tuberculosis in a University Hospital in Korea
다제내성 결핵의 치료 성적
- Yum, Ho-Kee (Dept. of Internal Medicine, Seoul Paik Hospital, Inje University) ;
- Song, Yeong-Su (Dept. of Internal Medicine, Seoul Paik Hospital, Inje University) ;
- Choi, Sao-Jean (Dept. of Internal Medicine, Seoul Paik Hospital, Inje University) ;
- Lee, Bong-Choon (Dept. of Internal Medicine, Seoul Paik Hospital, Inje University) ;
- Kim, Dong-Soon (Dept. of Internal Medicine, Asan Medical Center, College of Medicine, Ulsan University)
- 염호기 (인제대학교 서울백병원 내과학교실) ;
- 송영수 (인제대학교 서울백병원 내과학교실) ;
- 최수전 (인제대학교 서울백병원 내과학교실) ;
- 이봉춘 (인제대학교 서울백병원 내과학교실) ;
- 김동순 (울산대학교 의과대학 서울중앙병원 호흡기내과학교실)
- Published : 1996.12.30
Abstract
Background : Multidrug-resistant tuberculosis(MDR-Tb) has been increased not only in Asia but also in Western society, which may cause public health problems and reduce the efficacy of treatment of tuberculosis. In Western society HIV infection is believed to do a central role in increasing incidence of MDR tuberculosis, but MDR-Tb in Korea may be somewhat different about clinical features, underlying disorders, and prognosis. Goble et al reponed that overall treatment failure rate in MDR-Tb including resistance to isoniazid(INH) and rifampin (RFP) was 44 %. The aim of this study is to find the treatment result in Korea and the factors determining the prognosis. Methods: A retrospective study of pulmonary tuberculosis cultured M. tuberculosis from sputum or bronchial washing fluid between 1986 through 1992 was conducted in the Seoul Paik Hospital, Inje University. We reviewed clinical courses of 141 patients, who had a tuberculosis with resistance to 2 or more drugs including isoniazid(INH) and rifampin(RFP). One hundred and 4 patients of 141 patients had completed treatment and followed up for more than one year. Results: Of 104 (mean age