Korean Journal of Head & Neck Oncology (대한두경부종양학회지)
- Volume 12 Issue 2
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- Pages.153-160
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- 1996
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- 1229-5183(pISSN)
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- 2586-2553(eISSN)
Assessment of DNA Ploidy Patterns in Connection with Prognostic Factors in Patients with Papillary Thyroid Carcinoma
유두상 갑상선암에서 예후인자와 DNA배수성의 상관관계
- Chung Woung-Youn (Department of Surgery, College of Medicine, Yonsei University) ;
- Lee Jong-Hoon (Department of Surgery, College of Medicine, Yonsei University) ;
- Park Cheong-Soo (Department of Surgery, College of Medicine, Yonsei University)
- Published : 1996.11.01
Abstract
Regardless of the prognostic factors in papillary thyroid cancer, such as sex, age, size of tumor, extent of disease, and distant metastasis, the prognosis of papillary thyroid cancer is sometimes difficult to predict from clinical and microscopic analysis alone and additional prognostic indicators are needed. Recent studies of thyroid cancer have indicated that DNA aneuploidy may be correlated to the biological behavior of malignancy and inversely correlated to the prognosis, but it still remains contraversal. We performed this study to assess DNA ploidy patterns in relation with the previously known prognostic factors in AMES scoring system and lateral neck node metastasis in papillary thyroid cancer. A series of 132 patients with papillary thyroid cancer and 80 patients with benign thyroid tumor(27 follicular adenomas and 53 adenomatous goiters) as a control group from October 1993 to Feburary 1995 were analyzed and their nuclear DNA content was measured with flow cytometry using fresh tissue specimens. DNA aneuploidy was found in 8(6.1%) in papillary cancer and 8(10%) in benign tumor. S-phase traction(SFP) and proliferative index(PI) were higher in thyroid cancers, being 2.18