The Journal of Dong Guk Oriental Medicine (동국한의학연구소논문집)

  • Volume 5
  • /
  • Pages.131-147
  • /
  • 1996
  • /
  • 1226-556X(pISSN)
Research Institute of Oriental Medicine (동국대학교 한의학연구소)
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Effect of the Oryungsan on the injured liver in CCl4-treated rats

오령산(五?散)이 CCl4 투여(投與)로 인한 흰쥐의 손상간(損傷肝)에 미치는 영향(影響)

  • Kown, Oh Sung (Dept. of Internal Medicine, Oriental Medical College, Dongguk University) ;
  • Choi, Hong Sik (Dept. of Internal Medicine, Oriental Medical College, Dongguk University) ;
  • Lee, Joon Hee (Dept. of Internal Medicine, Oriental Medical College, Dongguk University) ;
  • Kang, Yoon Ho (Dept. of Internal Medicine, Oriental Medical College, Dongguk University)
  • 권오성 (동국대학교 한의과대학 내과학교실) ;
  • 최홍식 (동국대학교 한의과대학 내과학교실) ;
  • 이준희 (동국대학교 한의과대학 내과학교실) ;
  • 강윤호 (동국대학교 한의과대학 내과학교실)
  • Published : 1996.12.20
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Abstract

This study was investigated to define effect of pretreatment of Oryungsan on hepatotoxicity induced by $CCl_4$ in rat. The experimental anmals were divided into normal group, control group, sample group, and sample group were divided sample1, sample2, sample3. Control group were injected diluted carbon tetrachloride and olive oil, $1m{\ell}/kg$ to intraperitoneal after 8th day. Sample group were injected Oryungsan water extracts, $0.33m{\ell}/kg/day$ to intraperitoneal of sample group1, $0.66m{\ell}/kg$ day to sample group2, $1.32m{\ell}/kg/day$ to sample group 3 each other for 7day, and injected the dosage of $CCl_4$ was $1.0m{\ell}/kg$ diluted 1 : 1 with olive oil after 8th day. The following results were made by observation GOT, GPT, Albumin, Globulin, Bile acid, hepatic tissue. 1. The serum GOT and GPT level of sample group were decreased. Sample group 1 were decreased significantly. 2. The serum A/G ratio of sample group was increased as compared with normaI group. 3. The serum bile acid of sample group was decreased significantly. 4. The destruction of hepatic tissue were repaired as compared with control group. These results demonstrated that oryungsan can be attributed to recovery from hepatotoxicity.

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