Restorative Dentistry and Endodontics

The Korean Academy of Conservative Dentistry (대한치과보존학회)
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A STUDY ON THE CONCENTRATIONS OF LEUKOTRIENE B4 IN RELATION TO THE CLINICAL SYMPTOM OF PULPITIS IN HUMAN DENTAL PULP

치수염의 임상 증상과 치수내 Lekotriene B4의 농도에 관한 연구

  • Lim, Sung-Sam (Department of Conservative Dentistry, college of Dentistryl, Seoul National University) ;
  • Kwon, Hyuk-Choon (Department of Conservative Dentistry, college of Dentistryl, Seoul National University) ;
  • Yoon, Soo-Han (Department of Conservative Dentistry, college of Dentistryl, Seoul National University)
  • 임성삼 (서울대학교 치과대학 보존학교실) ;
  • 권혁춘 (서울대학교 치과대학 보존학교실) ;
  • 윤수한 (서울대학교 치과대학 보존학교실)
  • Published : 1996.03.20
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Abstract

The purpose of this study was to investigate the concentrations of Leukotriene B4 in relation to the clinical symptom of pulpitis in human dental pulp. Pulps obtained from 3 groups of teeth: normal uniflamed teeth(N=22), asymptomatic teeth with deep caries or large restorations(N = 21) and symptomatic teeth with the clinical diagnosis of irreversible pulpitis(N = 15). Pulps were dissected from normal un inflamed teeth and extirpated from asymptomatic and symptomatic teeth during routine endodontic treatment and stored in liquid nitrogen ($-70^{\circ}C$). The levels of Leukotriene B4 in individual or pooled pulps were measured by radioimmunoassay and the mean levels of each group were compared statistically(Kruskall-Wallis oneway ANOVA test). The results were as followings : 1. In normal pulp, low levels of Leukotriene B4 were measured. 2. In pulps from asymptomatic and symptomatic teeth had significantly higher levels of Leukotriene B4 than normal pulps(p<0.01). 3. The levels of Leukotriene B4 in pulps from symptomatic teeth were significantly higher than those of pulps from asymptomatic teeth(p<0.01). These results suggest that Leukotriene B4 play a cretain role in inflammatory process of dental pulp and have a relationship with clinical symptoms of pulpitis.

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