뇌혈관질환과 관상동맥성 심질환의 위험요인에 관한 환자-대조군 연구

The Case-Control Study on the Risk Factors of Cerebrovascular Diseases and Coronary Heart Diseases

  • 박종구 (연세대학교 원주의과대학 예방의학교실) ;
  • 김헌주 (연세대학교 원주의과대학 신경외과학교실) ;
  • 박금수 (연세대학교 원주의과대학 내과학교실) ;
  • 이성수 (연세대학교 원주의과대학 신경과학교실) ;
  • 장세진 (연세대학교 원주의과대학 예방의학교실) ;
  • 신계철 (연세대학교 원주의과대학 내과학교실) ;
  • 권상옥 (연세대학교 원주의과대학 내과학교실) ;
  • 고상백 (연세대학교 원주의과대학 예방의학교실) ;
  • 이은경 (연세대학교 원주의과대학 예방의학교실)
  • Park, Jog-Ku (Departments of Preventive Medicine, Yonsei University, Wonju College of Medicine) ;
  • Kim, Hun-Joo (Departments of Neurosurgery, Yonsei University, Wonju College of Medicine) ;
  • Park, Keum-Soo (Departments of Internal Medicine, Yonsei University, Wonju College of Medicine) ;
  • Lee, Sung-Su (Departments of Neurology, Yonsei University, Wonju College of Medicine) ;
  • Chang, Sei-Jin (Departments of Preventive Medicine, Yonsei University, Wonju College of Medicine) ;
  • Shin, Kye-Chul (Departments of Internal Medicine, Yonsei University, Wonju College of Medicine) ;
  • Kwon, Sang-Ok (Departments of Internal Medicine, Yonsei University, Wonju College of Medicine) ;
  • Ko, Sang-Baek (Departments of Preventive Medicine, Yonsei University, Wonju College of Medicine) ;
  • Lee, Eun-Kyoung (Departments of Preventive Medicine, Yonsei University, Wonju College of Medicine)
  • 발행 : 1996.09.01

초록

Cerebrovascular disease and coronary heart disease are the first and the fourth common causes of death among adults in Korea. Reported risk factors of these diseases are mostly alike. But some risk factors of one of these diseases may prevent other diseases. Therefore, we tried to compare and discriminate the risk factors of these diseases. We recruited four case groups and four control groups among the inpatients who were admitted to Wonju Christian Hospital from March, 1994 to November, 1995. Four control groups were matched with each of four case groups by age and sex. The number of patients in each of four case and control groups were 106 and 168 for acute myocardial infarction(AMI), 84 and 133 for subarachnoid hemorrhage(SAH), 102 and 148 for intracerebral hemorrhage(ICH), and 91 and 182 for ischemic stroke(IS) respectively. Factors whose levels were significantly higher in AMI and IS than in responding control group (RCG) were education, economic status, and triglyceride. Factors whose levels were significantly lower in hemorrhagic stroke than in RCG were age of monarch, and prothrombin time. The factor whose level was higher in AMI than ill RCG was uric acid. The factor whose level was higher in AMI, ICH, and SAM than in RCG was blood sugar. Factors whose levels were significantly higher in all the case groups than in RCG were earlobe crease, Quetelet index, white blood cell count, hemoglobin, hematocrit, and total cholesterol. The list of risk factors were somewhat different among the four diseases, though none of the risk factors to the one disease except prothrombin time acted as a preventive factor to the other diseases. The percent of grouped cases correctly classified was higher in the discrimination of ischemic diseases(AMI and IS) from hemorrhagic diseases(SAM and ICH) than in the discrimination of cerebrovascular disease from AMI. The factors concerned in the discrimination of ischemic diseases from hemorrhagic diseases were prothrombin time, earlobe crease, gender, age, uric acid, education, albumin, hemoglobin, the history of taking steroid, total cholesterol, and hematocrit according to the selection order through forward selection.

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