Journal of Preventive Medicine and Public Health
- 제29권3호
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- Pages.597-607
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- 1996
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
크롬에 의해 유발된 백서 임파구 DNA-Protein Crosslinks의 복구
Repair of Chromate induced DNA-Protein Crosslinks in Rat Lymphocyte
- Lee, Hun-Jae (Inha University Medical College, Department of Preventive Medicine) ;
- Lee, Kwan-Hee (Inha University Medical College, Department of Preventive Medicine) ;
- Hong, Yun-Chul (Inha University Medical College, Department of Preventive Medicine)
- 발행 : 1996.09.01
초록
Genotoxic agents can induce various DNA lesions. DNA-Protein Crosslinks(DPCs) were known as the important DNA lesions which could impair gene expression because DPCs had a high probability of resisting repair and persisting through cell cycle. This repair resistance of DPCs could have biological significance but had not been evaluated clearly yet. Most of the studies that have evaluated the repair of DPCs only compared the extent of DPCs repair with other DNA lesions. We injected