Journal of Preventive Medicine and Public Health
- Volume 29 Issue 3 Serial No. 54
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- Pages.597-607
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- 1996
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Repair of Chromate induced DNA-Protein Crosslinks in Rat Lymphocyte
크롬에 의해 유발된 백서 임파구 DNA-Protein Crosslinks의 복구
- Lee, Hun-Jae (Inha University Medical College, Department of Preventive Medicine) ;
- Lee, Kwan-Hee (Inha University Medical College, Department of Preventive Medicine) ;
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Hong, Yun-Chul
(Inha University Medical College, Department of Preventive Medicine)
- Published : 1996.09.01
Abstract
Genotoxic agents can induce various DNA lesions. DNA-Protein Crosslinks(DPCs) were known as the important DNA lesions which could impair gene expression because DPCs had a high probability of resisting repair and persisting through cell cycle. This repair resistance of DPCs could have biological significance but had not been evaluated clearly yet. Most of the studies that have evaluated the repair of DPCs only compared the extent of DPCs repair with other DNA lesions. We injected