Journal of Preventive Medicine and Public Health
- Volume 29 Issue 1 Serial No. 52
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- Pages.27-41
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- 1996
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Scientific rationale and applicability of dose-response models for environmental carcinogens
환경성 발암물질의 용량-반응모델의 이론적 근거와 응용에 관한 연구 - 음용수 중 chloroform을 중심으로
- Shin, Dong-Chun (Department of Preventive Medicine and Institute for Environmental Research, Yonsei University College of Medicine) ;
- Chung, Yong (Department of Preventive Medicine and Institute for Environmental Research, Yonsei University College of Medicine) ;
- Kim, Jong-Man (Department of Preventive Medicine and Institute for Environmental Research, Yonsei University College of Medicine) ;
- Lee, Seong-Im (Department of Preventive Medicine and Institute for Environmental Research, Yonsei University College of Medicine) ;
- Hwang, Man-Sik (Department of Preventive Medicine and Institute for Environmental Research, Yonsei University College of Medicine)
- 신동천 (연세대학교 의과대학 예방의학교실 및 환경공해연구소) ;
- 정용 (연세대학교 의과대학 예방의학교실 및 환경공해연구소) ;
- 김종만 (연세대학교 의과대학 예방의학교실 및 환경공해연구소) ;
- 이성임 (연세대학교 의과대학 예방의학교실 및 환경공해연구소) ;
- 황만식 (연세대학교 의과대학 예방의학교실 및 환경공해연구소)
- Published : 1996.03.01
Abstract
This study described methods to predict human health risk associated with exposure to environmental carcinogens using animal bioassay data. Also, biological assumption for various dose-response models were reviewed. To illustrate the process of risk estimate using relevant dose-response models such as Log-normal, Mantel-Bryan, Weibull and Multistage model, we used four animal carcinogenesis bioassy data of chloroform and chloroform concentrations of tap water measured in large cities of Korea from 1987 to 1995. As a result, in the case of using average concentration in exposure data and 95% upper boud unit risk of Multistge model, excess cancer risk(RISK I) was about
Keywords
- environmental carcinogens;
- dose-response model;
- chloroform;
- excess cancer risk;
- Monte-Carlo analysis