Korean Journal of Veterinary Research (대한수의학회지)
- Volume 36 Issue 3
- /
- Pages.599-605
- /
- 1996
- /
- 2466-1384(pISSN)
- /
- 2466-1392(eISSN)
Nitric oxide(NO)-mediated relaxation of bovine retractor penis muscle
소 음경후인근의 Nitric oxide(NO) 매개성 이완
-
Yang, Il-suk
(Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University) ;
- Chang, Hee-jung (Chorok Animal Clinic) ;
- Kang, Tong-mook (Samsung Biomedical Research Institute) ;
-
Lee, Jang-hern
(Department of Veterinary Physiology, College of Veterinary Medicine, Seoul National University)
- Received : 1996.06.03
- Published : 1996.09.25
Abstract
This study was designed to examine the mechanism of penile erection in adult bull by analyzing the responses of bovine proximal retractor penile muscle strips(BRP) to electtical field stimulation(EFS), exogenous nitric oxide(NO), NO synthesis precursor(L-arginine), NO synthase inhibitors(L-NAME, L-NMMA), guanylate cyclase inhibitor(methylene blue) and nonspecific potassium channel blocker(tetraethylammonium, TEA) treatments. Isometric tension of BRP was measured using physiograph. Results were summarized as follows: 1. EFS of nonadrenergic noncholinrgic(NANC) nerve in BRP produced frequency-dependent inhibitory responses to the contraction induced by co-treatment of epinephrine, guanethidine and atropine. The inhibitory responses to EFS were blocked by tetrodotoxin(TTX,
Keywords
- Bovine retractor penis muscle;
- nitric oxide;
- Nw-nitro-L-arginine methyl ester(L-NAME);
- L-arginine;
- cGMP;
- K+ channel