Journal of Periodontal and Implant Science
- 제26권4호
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- Pages.873-887
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- 1996
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
PDGF-BB 적용시간이 decalcified dentin에서의 치은섬유아세포의 증식에 대한 효과
The Influence of PDGF-BB Application Time on the Proliferation of HGF Using Decalcifed Dentin
- Park, Jin-Woo (Department of periodontology, School of Dentistry, Kyungpook National University) ;
- Lee, Jae-Mok (Department of periodontology, School of Dentistry, Kyungpook National University) ;
- Sun, Jo-Young (Department of periodontology, School of Dentistry, Kyungpook National University)
- 발행 : 1996.12.31
초록
Platelet-derived growth factor(PDGF) is one of the polypeptide growth fators. PDGF has been reported as a biological mediator which regulates activities of wound healing process including the cell proliferation, migration and metabolism. Recent studies indicated that demineralized root surface as the primary site for growth factor application has advantages over other application method, especially due to binding capacity of growth factor for exposed matrix component of deminera1ized dentin surface. The purpose of this study is to evaluate optimal application time of PDGF-BB on proliferation of human gingival fibroblasts using deminera1ized dentin surface as primary application site. Human gingival fibroblasts and dentin slabs were prepared from the first premolar tooth extracted for the orthodontic treatment, cells were cultured in DMEM/I0% FBS at the
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