Journal of Periodontal and Implant Science
- Volume 26 Issue 4
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- Pages.799-821
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- 1996
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
THE EFFECTS OF PLATELET DERIVED GROWTH FACTOR-BB AND INSULIN-LIKE GROWTH FACTOR-I ON THE REGENERATION OF PERIODONTIUM IN THE DEHISCENCE DEFECTS OF DOGS
성견의 열개형 골 결손부에서 PDGF-BB와 IGF-l 치주조직 치유에 미치는 영향
- Son, Hyo-Sang (Department of Periodontology, College of Dentistry, Yonsei University) ;
- Cho, Kyoo-Sung (Department of Periodontology, College of Dentistry, Yonsei University)
- Published : 1996.12.31
Abstract
The ultimate goal of periodontal treatment has been to facilitate regeneration of diseased periodontal tissues, destroyed by inflammatory periodontal disease. For regeneration of the periodontium to occur, all of component tissues must be restored to their original position and architecture. Growth factors which were known to promote the cellular processes, ie, proliferation, migration and matrix synthesis, have been in the spotlight of current periodontics. Platelet-derived growth factor(PDGF) stimulates collagen and non collagen protein synthesis, migration and proliferation of periodontal ligament cells. Insulin-like growth factor(IGF) has potentials to induce collagen and bone matrix synthesis so that it regulates normal bone remodeling. Application of the combination have been known to facilitate formation of bone and cementum, and to synergistically interact to promote coronal migration and proliferation of periodontal ligament cells. These two growth factors have been reported to exhibit positive effect in the periodontally diseased teeth or class m furcation defects. The aim of the present study was to test the hypothesis that PDGF-BB alone or the combination of PDGF-BB and IGF-I can predictably enhance regeneration of the periodontium in the dehiscence defect. Following the resection of premolars, roots were embedded. After 12 weeks of healing period, standardized experimental