Journal of Periodontal and Implant Science
- 제26권3호
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- Pages.641-654
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- 1996
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
황련이 Lipopolysaccharide를 처리한 치주인대세포의 세포활성 및 IL-6 생산에 미치는 영향
Effects of Rhizoma Coptidis on Cellular Activity and IL-6 Production of LPS-treated Periodontal Ligament Cells
- 송기범 (원광대학교 치과대학 치주과학교실) ;
- 공영환 (원광대학교 치과대학 치주과학교실) ;
- 유형근 (원광대학교 치과대학 치주과학교실) ;
- 신형식 (원광대학교 치과대학 치주과학교실)
- Song, Ki-Bum (Dept. of Periodontology, College of Dentistry, Wonkwang University) ;
- Kong, Young-Hwan (Dept. of Periodontology, College of Dentistry, Wonkwang University) ;
- You, Hyung-Keun (Dept. of Periodontology, College of Dentistry, Wonkwang University) ;
- Shin, Hyung-Shik (Dept. of Periodontology, College of Dentistry, Wonkwang University)
- 발행 : 1996.09.30
초록
In infectious disease, invasion of host tissue by bacteria or their products frequently induces a wide variety of inflammatory and immunopathologic reaction. Evidence indicates that cytokines are involved in the initiation and progression of chronic inflammatory diseases, such as periodontitis. Interleukin-6, which is a multifunctional cytokine, has important roles in acute and chronic inflammation and may also be implicated in bone resorption. Periodontal diseases are characterized by chronic inflammation of the periodontium with alveolar bone resoption. A principal driving force behind this response appears to lie in the immune system's response to bacteria. Many of the cell components which have been shown to function as virulence factors in gram-negative bacteria are associated with the bacterial surface. Of these, lipopolysaccharide has been characterized as one that mediates a number of biological activities which can lead to the destruction of host tissue. Non-steroidal antiinflammatory drug is used for reduce inflammation, and most of NSAIDs inhibit prostaglandine
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