Journal of Periodontal and Implant Science
- 제26권1호
- /
- Pages.317-333
- /
- 1996
- /
- 2093-2278(pISSN)
- /
- 2093-2286(eISSN)
Flurbiprofen 함유 키토산 제제가 치은 섬유아세포에 미치는 영향
Biological Effects Of Flurbiprofen Loaded Chitosan To Gingival Fibroblast
- 정종평 (서울대학교 치과대학 치주과학교실) ;
- 박윤정 (이화여자대학교 약학대학) ;
- 이승진 (이화여자대학교 약학대학) ;
- 유인철 (서울대학교 치과대학 치주과학교실) ;
- 최상묵 (서울대학교 치과대학 치주과학교실)
- Chung, Chong-Pyoung (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
- Park, Yoon-Jeong (Dept. of Industrial Pharmacy, College of Pharmacy, Ewha Womans University) ;
- Lee, Seung-Jin (Dept. of Industrial Pharmacy, College of Pharmacy, Ewha Womans University) ;
- Rhyu, In-Cheol (Dept. of Periodontology, College of Dentistry, Seoul National University) ;
- Choi, Sang-Mook (Dept. of Periodontology, College of Dentistry, Seoul National University)
- 발행 : 1996.03.30
초록
The main goal of periodontal regeneration is to be achieved by epithelial exclusion, periodontal ligament cell activation or alveolar bone regeneration. The purpose of this study was to investigate on the physico- chemical and biological characteristics of biodegradable chitosan beads. Chitosan beads were fabricated by ionic gelation with sodium tripolyphosphate and they had the size in 300um diameter. As therapeutic agent, flurbiprofen was incorporated into the beads by 10, 20% loading contents. The release of drugs from the chitosan beads was measured in vitro. Also, biological activity tests of flurbiprofen loaded chitosan beads including cytotoxicity test, ihhibition of