Journal of Korean Academy of Oral and Maxillofacial Radiology (치과방사선)

Korean Academy of Oral and Maxillofacial Radiology (대한영상치의학회)
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AN EXPERIMENTAL STUDY OF EXTRACTION WOUND HEALING IN THE CALCIUM DEFICIENT RAT

저칼슘식이가 백서의 발치창 치유에 미치는 영향에 관한 실험적 연구

  • Yoo Young-Sun (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
  • Hwang Eui-Hwan (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University) ;
  • Lee Sang-Rae (Department of Oral and Maxillofacial Radiology, College of Dentistry, Kyung Hee University)
  • 유영선 (경희대학교 치과대학 구강악안면방사선학 교실) ;
  • 황의환 (경희대학교 치과대학 구강악안면방사선학 교실) ;
  • 이상래 (경희대학교 치과대학 구강악안면방사선학 교실)
  • Published : 1996.08.01
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Abstract

The purpose of this study was to investigate effects of osteoporosis on extraction wound healing in the calcium deficient rat. In order to carry out this study, ten-week old Wistar strain rats weighing about 300 gms were selected. When the rats reached thirteen-week old, rats' mandibular first molars were removed. The rats were then divided into three groups: Group l(rats given a normal diet both before and after tooth extraction), Group 2(rats given a low calcium diet for three weeks before tooth extraction and a normal diet after tooth extraction), and Group 3(rats given a low calcium diet for three weeks before and after tooth extraction). The healing of extraction wounds, as assessed by microradiography, autoradiography, and histopathologic examination, were compared among these three groups. The obtained results were as follows : I. In Group 1, newly formed bone and active uptake of 45Ca around extraction wound were noted on the 3rd and the 7th day. On the 14th and the 21st day, the extraction wounds of this group showed the bone trabecular formation and active 4Ca uptake in the extraction wound and alveolar crest. The more prominent bone trabeculae with a less uptake of /sup 45/Ca were noted on the 42nd day. 2. In Group 2, newly formed bone and thinning of alveolar bone trabeculae with more extensive uptake of /sup 45/Ca than that in Group 1 were noted on the 3rd and the 7th day. On the 14th day, bone trabeculae were less thicker than that in Group 1. The prominent bone trabeculae in the extraction wounds and alveolar crest were noted on the 21st and the 42nd days. 3. In Group 3, newly formed bone was noted on the 3rd and the 7th day. Alveolar bone trabeculae and uptake of /sup 45/Ca were similar to that in Group 2. On the 14th and 21st day, bone trabeculae were less thicker than that in Group 2 and Group 3. The osteoporotic change with active uptake of /sup 45/Ca was markedly noted on the 42nd day.

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