Aminopeptidase M 저해제인 Valistatin과 des-Asp$^4$-Amastatin을 생산하는 방선균 SL20209의 특성 및 동정

Characterization and Identification of Streptomyces SL20209 Producing Valistatin and des-Asp$^4$-Amastatin, Two Inhibitors of Aminopeptidase M.

  • 고학룡 (한국과학기술연구원, 생명공학연구소, 미생물화학연구그룹) ;
  • 전효곤 (한국과학기술연구원, 생명공학연구소, 미생물화학연구그룹) ;
  • 정명철 (한국과학기술연구원, 생명공학연구소, 미생물화학연구그룹) ;
  • 서현효 (한국과학기술연구원, 생명공학연구소, 응용미생물연구그룹) ;
  • 김홍중 (한국과학기술연구원, 생명공학연구소, 유전자은행) ;
  • 박용하 (한국과학기술연구원, 생명공학연구소, 유전자은행) ;
  • 고영희 (한국과학기술연구원, 생명공학연구소, 미생물화학연구그룹)
  • Ko, Hack-Ryong (Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Chun, Hyo-Kon (Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Chung, Myung-Chul (Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Suh, Hyun-Hyo (Applied Microbiology Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Hong-Joong (Korean Collection for Type Culture, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Park, Yong-Ha (Korean Collection for Type Culture, Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kho, Yung-Hee (Microbial Chemistry Research Group, Korea Research Institute of Bioscience and Biotechnology, KIST)
  • 발행 : 1996.02.01

초록

Characterization and numerical identification were carried out for an actinomycetes SL20209. Morphological, cultural and physiological perperties of SL20209 which porduced valistatin and des-$asp^4$-amastatin as inhibitors of aminopeptidase M were evaluated. The isolate was identified to be the genus of Streptomyces. Fourty-three taxonomic units were analysed by using a TAXON program. The isolate was classified into the major cluster 29 of Streptomyces and best-matched to Streptomyces griseoplanus.

키워드