약학회지 (YAKHAK HOEJI)
- 제40권1호
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- Pages.90-94
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
6-[(N-4-플루오로페닐)아미노-7-클로로-5,8-퀴놀린디온의 in vivo 향진균 작용 평가
The Evaluation of in Vivo Antifungal Activities of 6-[(N-4-Fluorophenyl)amino-7-Chloro-5,8-Quinolinedione
- 박윤미 (이화여자대학교 약학대학) ;
- 김희정 (이화여자대학교 약학대학) ;
- 김도희 (이화여자대학교 약학대학) ;
- 이인경 (이화여자대학교 약학대학) ;
- 김동현 (경희대학교 약학대학) ;
- 유충규 (이화여자대학교 약학대학)
- Park, Yun-Mi (College of Pharmacy, Ewha Womens University) ;
- Kim, Hee-Jeong (College of Pharmacy, Ewha Womens University) ;
- Kim, Do-Hee (College of Pharmacy, Ewha Womens University) ;
- Lee, In-Kyung (College of Pharmacy, Ewha Womens University) ;
- Kim, Dong-Hyun (College of Pharmacy, Kyung Hee University) ;
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womens University)
- 발행 : 1996.02.01
초록
6-[(N-4-Fluorophenyl)amino]-7-chloro-5,8-quinolinedione(RCK3) was tested for antifungal activities, in vivo, against Candida albicans. RCK3 was compared with ketoc onazole and fluconazole in the treatment of systemic infection with Candida albicans in normal mice. The therapeutic potential of RCK3 had been assessed by evaluating their activities (survival rate) against systemic infections in normal mice. RCK3 had