YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Inhibitory Effect of Glycyrrhizin on the Lethality Induced by Lippolysaccharide and Galactosamine

리포폴리사카라이드와 갈락토사민의 투여로 인한 생쥐 치사율에 미치는 글리시리진의 억제효과

  • Oh, Chang-Wook (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University) ;
  • Song, Kyung (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University) ;
  • Park, Eun-Jeon (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University) ;
  • Sohn, Dong-Hwan (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University) ;
  • Kim, Jae-Baek (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University) ;
  • Ko, Geon-Il (College of Pharmacy, Institute of Pharmaceutical Research and Development, Medicinal Resources Research Center, Wonkwang University)
  • 오창욱 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 송경 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 박은전 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 손동환 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 김재백 (원광대학교 약학대학, 약품연구소, 의약자원연구센타) ;
  • 고건일 (원광대학교 약학대학, 약품연구소, 의약자원연구센타)
  • Published : 1996.02.01
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Abstract

This study was done to investigate the effect of glycyrrhizin on the lethality induced by galactosamine and lipopolysaccharide coadministration in mice. Glycyrrhizin was injecte d intravenously as a multiple dose at 20, 15, 10, 5, and O hr before galactosamine and lipopolysaccharide coadministration. Lethality and tumor necrosis factor (TNF${\alpha}$) level in serum were surveyed as markers of glycyrrhizin effect. Glycyrrhizin had no effect on the lethality induced by galactosamine and lipopolysaccharide when glycyrrhizin was administered as a single dose. Glycyrrhizin reduced the lethality induced by galactosamine and LPS in dose-dependent manner when glycyrrhizin was administered as a multiple dose at 20, 15, 10, 5 and O hr before galactosamine and lipopolysaccharide coadministration. Glycyrrhizin reduced the serum TNF${\alpha$ level.

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