YAKHAK HOEJI (약학회지)
- Volume 40 Issue 5
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- Pages.574-581
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Protective Effect of Marine Natural Products on the Hepatic Lipid Peroxidation in Acetaminophen-treated Rats
아세트아미노펜 유도 흰쥐에서 수산생물자원 추출물의 in vivo 간보호작용
- Choe, Jong-Won (College of Pharmacy, Kyongsung University) ;
- Park, Jong-Cheol (Department of Oriental Medicine Resources, Sunchon National University)
- Published : 1996.10.01
Abstract
The study was initiated to elucidate the protective mechanism by examining in vivo effect of some marine natural products, Styela plicata, Ecklonia stolonifera and Pachymeniopsis elliptica on acetaminophen-induced lipid peroxidation. The methanol extract of S. plicata prevented acetaminophen (800mg/kg, i.p.)-induced hepatotoxicity in rats as evidenced by the decreased formation of lipid peroxide. But the methanol extracts of E. stolonifera and P. elliptica were not affected on the formation of lipid peroxidation. The activities of cytochrome P-450, animopyrine N-demethylase and aniline hydroxylase were not changed by the treatment with S. plicata in comparison with acetaminophen-teated group. In acetaminophen-treated control rats, the glutathione S-transferase activity was decreased markably. However. in S. plicata pretreated group, the effect caused by acetaminophen was markably reduced. A-cetaminophen decreased the level of hepatic, glutathione, which was restored to same degree by S. plicata pretreatment. And activity of
Keywords
- Stuela plicata;
- acetaminophen-treated rat;
- lipid peroxide;
- glutathione S-transferase;
- glutathione reductase;
- marine natural product;
- anti-hepatotoxicity