약학회지 (YAKHAK HOEJI)
- 제40권5호
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- Pages.539-544
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- 1996
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
(-)-4-(파라클로로비페닐)-2-히드록시테트론 산의 합성
Synthesis of (-)-4-(p-Chlorobiphenyl)-2-hydroxytetronic Acid
- 권순경 (덕성여자대학교 약학대학) ;
- Gwon, Sun-Gyeong (College of pharmacy, Duk-Sung Women's University) ;
- Witiak, Donald T. (School of pharmacy, University of Wisconsin Madison)
- 발행 : 1996.10.01
초록
4-Aryl-2-hydroxytetronic acids which can be construded as a "lipophilic vitamin C analogue", are known to have antilipidemic and antiaggregatory activities in stead of antiscorb utic activity of vitamin C. A new compound 4-(p-chlorobiphenyl)-2-hydroxytetronic acid (8), which is structurally closely connected with the most active 4-(p-chlorophenyl)-2-hydroxytetronic acid, was synthesized from alpha-(p-chlorobiphenyl)-alpha-hydroxyacetic acid (1) through 7 steps as a potentially bioactive compound.
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